反应详情

To a solution of the product from step (ii) (0.7 g) in DMSO (5 ml) was added cesium carbonate (0.75 g). After 5 minutes a solution of 3-bromomethylbenzoic acid methyl ester (0.53 g) in DMSO (5 ml) was added. The mixture was stirred at room temperature for 20 minutes and partitioned between ethyl acetate and water. The organic phase was washed with water and brine, dried (MgSO4) and evaporated. Purified by chromatography eluting with 30% ethyl acetate in isohexane. Yield 0.34 g.

1. custompartitioned between ethyl acetate and water
2. washThe organic phase was washed with water and brine
3. dry with materialdried (MgSO4)
4. customevaporated
5. customPurified by chromatography
6. washeluting with 30% ethyl acetate in isohexane