HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Bis(bromomethyl)benzoic acid ethyl ester → 3-Bromomethyl-5-{ethoxymethyl}benzoic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Bis(bromomethyl)benzoic acid ethyl ester | HCID 15440343 | — |
| Reactant | Potassium ethoxide | HCID 23670592 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Bromomethyl-5-{ethoxymethyl}benzoic acid, ethyl ester | HCID 131722429 | — |
Reaction Steps
A stirred solution of 3,5-bis[bromomethyl]benzoic acid ethyl ester (3g) in ethanol (100 ml) was treated with potassium ethoxide (0.75 g) and stirred overnight. The mixture was partitioned between ethyl acetate and water. The organic phase was dried (MgSO4) and evaporated and the residue purified by chromatography eluting with 10% ethyl acetate in isohexane. Yield 1.3 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06200981B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-9466452d05ac4296b29514a64a1baec8 |
| Source note | uspto-grants-2001_03 |