反应详情

N-[1-Acetyl-3-(2-ethoxycarbonylethyl)-4,6-dimethylindolin-7-yl]-2,2-dimethylpropanamide (2.6 g) was dissolved in EtOH (40 ml), and a solution of KOH (1.3 g) in water (10 ml) was added, which was followed by refluxing for 20 hr. EtOH was evaporated under reduced pressure, and the mixture was adjusted to pH 5 with 2N hydrochloric acid and extracted with CHCl3 (100 ml). The CHCl3 layer was washed with water and dried over anhydrous sodium sulfate, CHCl3 was evaporated under reduced pressure to give 1.5 g of N-[3-(2-carboxyethyl)-4,6-dimethylindolin-7-yl]-2,2-dimethylpropanamide. 1H-NMR (CDCl3) δ

1. temperatureby refluxing for 20 hr
2. customEtOH was evaporated under reduced pressure
3. extractionextracted with CHCl3 (100 ml)
4. washThe CHCl3 layer was washed with water
5. dry with materialdried over anhydrous sodium sulfate, CHCl3
6. customwas evaporated under reduced pressure