HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylamine → N-ethyl-2-chloro-5-nitrobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Benzoyl chloride, 2-chloro-5-nitro- | HCID 117637 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-ethyl-2-chloro-5-nitrobenzamide | HCID 4380195 | 86% |
Reaction Steps
Alternatively, 2-chloro-5-nitrobenzoyl chloride (10 g, 45.5 mmol) in anhydrous dichloromethane (250 mL) with Amberlyst A-21 ion-exchange resin (17 g) was treated with a 2M THF solution of ethylamine (45 mL). The mixture was stirred at rt under nitrogen overnight. After filtration, the filtrate was concentrated to give N-ethyl-2-chloro-5-nitrobenzamide (9.0 g, 39 mmol, 86% yield) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06200995B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-12290228db9b454f9902bdcf803eb53f |
| Source note | uspto-grants-2001_03 |