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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1532Generated: October 26, 2026

tert-butyl N-(2-(4-hydroxyphenyl)ethyl)carbamate → 4-(2-t-Butoxycarbonylaminoethyl)phenoxymethyl-(3-benzyloxypropyl)phosphinic acid, n-butyl ester

https://huagongshe.com/reaction/1532

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-butyl N-(2-(4-hydroxyphenyl)ethyl)carbamateHCID 11831452—
Reactant3-Benzyloxypropyl-(4-chlorobenzenesulfonyloxymethyl)phosphinic acid, n-butyl esterHCID 86752195—
Product4-(2-t-Butoxycarbonylaminoethyl)phenoxymethyl-(3-benzyloxypropyl)phosphinic acid, n-butyl esterHCID 86752194—

Reaction Steps

The title compound was prepared from 3-benzyloxypropyl-(4-chlorobenzenesulfonyloxymethyl)phosphinic acid, n-butyl ester and 2-(4-hydroxyphenyl)ethylcarbamic acid, t-butyl ester according to the procedure described in Procedure 24. The crude product was purified by chromatography, eluting with dichloromethane containing 3% methanol, to give an oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05726165
Source datasetuspto-grants-1998_03
ORD IDord-d7fbc646e6f24341bd3baed08edf1bc8
Source noteuspto-grants-1998_03