3,4-Difluorophenol → HCID 22993851, compound

HRID 1532004Notes

Reaction equation

HRID 1532004 reaction equation
Cl[C:2]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[F:16][C:17]1[CH:18]=[C:19]([OH:24])[CH:20]=[CH:21][C:22]=1[F:23]>>[N+:13]([C:10]1[CH:11]=[CH:12][C:2]([O:24][C:19]2[CH:20]=[CH:21][C:22]([F:23])=[C:17]([F:16])[CH:18]=2)=[C:3]([CH:9]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5])([O-:15])=[O:14]

Participants

3

Reactant 2

HCID 759273,4-DifluorophenolHCID 2774222ethyl 2-chloro-5-nitrobenzoate

Product 1

HCID 22993851HCID 22993851, compoundYield 94.7%

Procedure

Using the method described in Example 21.2, ethyl 2-chloro-5-nitrobenzoate (0.6 g) and 3,4-difluorophenol (0.34 g) were combined to provide 0.8 g of the title compound as an oil.

Sources & evidence

ORD record
ord-d6b26d276a1a4235b85f5ab2b92bc663
Source dataset
uspto-grants-2001_03
Patent number
US06200995B1

Reaction notes

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