p-Fluoronitrobenzene → 5-(4-Nitrophenoxy)-3-chloropyridine

HRID 1532007Notes

Reaction equation

HRID 1532007 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[Cl:11][C:12]1[CH:13]=[N:14][CH:15]=[C:16]([OH:18])[CH:17]=1>>[Cl:11][C:12]1[CH:13]=[N:14][CH:15]=[C:16]([O:18][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)[CH:17]=1

Participants

3

Reactant 2

HCID 9590p-FluoronitrobenzeneHCID 5823053-Hydroxy-5-chloropyridine

Product 1

HCID 121093595-(4-Nitrophenoxy)-3-chloropyridineYield 87.6%

Procedure

4-Fluoro-nitrobenzene (5.0 g) and 3-chloro-5-hydroxypyridine (4.59 g) were combined at 60° C. using a method similar to that of Example 21.2 to provide 7.78 g of 4-(3-chloro-5-pyridyloxy)nitrobenzene. mp 80-82° C.

Workup

  1. customwere combined at 60° C.

Sources & evidence

ORD record
ord-51e1c8b247084dbc8b96b46a2a4809bd
Source dataset
uspto-grants-2001_03
Patent number
US06200995B1

Reaction notes

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