1-Fluoro-2-nitrobenzene → HCID 22993890, compound

HRID 1532008Notes

Reaction equation

HRID 1532008 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[Cl:11][C:12]1[CH:13]=[N:14][CH:15]=[C:16]([OH:18])[CH:17]=1>>[Cl:11][C:12]1[CH:13]=[N:14][CH:15]=[C:16]([O:18][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[N+:8]([O-:10])=[O:9])[CH:17]=1

Participants

3

Reactant 2

HCID 738951-Fluoro-2-nitrobenzeneHCID 5823053-Hydroxy-5-chloropyridine

Product 1

HCID 22993890HCID 22993890, compoundYield 96.4%

Procedure

2-Fluoro-nitrobenzene (5.0 g) and 3-chloro-5-hydroxypyridine (4.59 g) were combined at 80° C. for 1 hr, using a method similar to that of Example 21.2 to provide 8.56 g of 2-(3-chloro-5-pyridyloxy)nitrobenzene.

Sources & evidence

ORD record
ord-96a87f8e06ac47e8ab4080a23ef80a13
Source dataset
uspto-grants-2001_03
Patent number
US06200995B1

Reaction notes

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