Hydrochloric Acid → HCID 178470546, compound

Participants

Reaction Steps

3-Hydroxy-4-methylisoxazole-5-carboxylic acid (6.0 g, 42 mmol) and a saturated solution of HCl in EtOH (110 mL) was boiled under reflux for 4 h. The solution was concentrated in vacuo and the residue dissolved in EtOAc, dried (MgSO4) and evaporated in vacuo to give crude title compound (7.2 g, 100%). A small sample was recrystallized (EtOAc/heptane) to give colorless crystals: mp 133-134° C. The crude product was used in the next step without further purification.

Provenance & Evidence