Hydrochloric Acid → HCID 86756536, compound

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Reaction Steps

A mixture of benzyl (RS)-2-[(tert-butoxycarbonyl)amino]-3-(5-benzyloxycarbonyl-3-ethoxyisoxazol-4-yl)propionate (1.9 g, 3.6 mmol) and a saturated solution of HCl in dietyl ether (40 mL) was boiled under reflux for 2 h. The formed crystals were collected by filtration, stirred with ethyl acetate, and collected by filtration (0.53 g, 32%): mp 142-144° C.; 1H NMR (DMSO-d6) δ1.32 (t, 3 H), 3.17 (dd, 1 H), 3.25 (dd, 1 H), 4.17-4.32 (m, 3 H), 5.09 (dd, 2 H), 5.39 (s, 2 H), 7.24-7.53 (m, 10 H); MS ((M+H)+) m/z 425. Anal. calcd, C, 59.93; H, 5.48; N, 6.08; found, C, 59.70; H, 5.49; N, 6.26.

Provenance & Evidence