HCID 10755030, compound → HCID 10736209, compound

Participants

Reaction Conditions

Reaction Steps

A solusion of ethyl 4-bromomethyl-3-ethoxyisoxazole-5-carboxylate (5 g, 17.9 mmol) in DMF (85 mL) was added to a suspension of potassium phthalimid (3.6 g, 19,7 mmol) in DMF (125 mL) at 90° C. The resulting mixture was stirred at 90° C. for 40 min, then cooled and concentrated in vacuo. Water (250 mL) was added and the aqueous phase was extracted with diethylether (2×200 mL). The organic extracts were dried (MgSO4) and concentrated in vacuo to give a crude product which was recrystallized (EtOH) to yield the title compound (3.70 g, 60%): mp 93-94° C.

Provenance & Evidence