Sodium Hydroxide → HCID 135738567, compound

Participants

Reaction Steps

A solution of 5-(2-ethoxybenzamido)-1-n-propyl-pyrazole-4-carboxamide (Preparation 2; 0.541 g, 0.0017 mol) and sodium hydroxide (0.10 g, g, 0.0026 mol) in a mixture of water (5 ml) and ethanol 1 ml) was heated under reflux for 20 hours. The cool reaction solution was extracted with dichloromethane (5×30 ml), then the combined extracts dried (Na2SO4) and evaporated under vacuum to give the crude product. Purification by column chromatography (SiO2, 5% MeOH in CH2Cl2) afforded the title compound as a white solid (0.45 g, 89%). Crystallisation of a sample from ethyl acetate-hexane gave colourless needles, m.p. 154-155° C. Found: C,64.45; H,5.97; N,18.89. C16H18N4O2 requires C,64.41; H,6.08; N,18.78%.

Provenance & Evidence