HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzamidine, hydrochloride → 2-(2-Propoxyphenyl)-8-phenylpurin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzamidine, hydrochloride | HCID 80289 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 5,6-Diamino-2-(2-propoxyphenyl)pyrimidin-4(3H)-one | HCID 135709856 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(2-Propoxyphenyl)-8-phenylpurin-6-one | HCID 21250749 | — |
Reaction Conditions
| Temperature | 165 °C |
|---|
Reaction Steps
A mixture of 4,5-diamino-2-(2-propoxyphenyl)-pyrimidine-6-one (1.3 g), benzamidine hydrochloride (2 g) and anhydrous sodium acetate (0.9 g) was heated in an oil bath (temperature 160-170° C.) for 2 hours. The reaction mixture was digested with hot ethanol to give a solid, 0.76 g, m.p. 267-271° C. This was combined with a further sample, 0.2 g, (similarly prepared) and recrystallised from aqueous acetic acid to give the title compound, 0.74 g, m.p. 259-260° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06200980B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-606d07fb233e447fb5bdcbe1184c8fb3 |
| Source note | uspto-grants-2001_03 |