HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetamidine monohydrochloride → 2-(2-Propoxyphenyl)-8-methylpurin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetamidine monohydrochloride | HCID 67170 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 5,6-Diamino-2-(2-propoxyphenyl)pyrimidin-4(3H)-one | HCID 135709856 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(2-Propoxyphenyl)-8-methylpurin-6-one | HCID 21250697 | — |
Reaction Conditions
| Temperature | 155 °C |
|---|
Reaction Steps
A mixture of 4,5-diamino-2-(2-propoxyphenyl)pyrimidin-6-one (1.56 g), anhydrous sodium acetate (1.14 g) and acetamidine hydrochloride (1.42 g) was heated in an oil bath at 150-160° C. for 2 hours. The mixture was digested with ethanol (2 ml), cooled, filtered and the solid washed with ethanol. Recrystallisation from ethanol gave the title compound, 0.72 g, m.p. 264-265° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06200980B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-96de353ca61445fb9ccd80ff0d4d10fa |
| Source note | uspto-grants-2001_03 |