Formamide → HCID 18409955, compound

HRID 1532127Notes

Reaction equation

HRID 1532127 reaction equation
S(O)(O)(=O)=O.[NH2:6][C:7]1[N:8]=[C:9]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[O:21][CH2:22][CH2:23][CH3:24])[NH:10][C:11](=[O:14])[C:12]=1[NH2:13].S(=O)(=O)(O)O.[CH:30](N)=O>>[CH2:22]([O:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:9]1[N:8]=[C:7]2[C:12](=[N:13][CH:30]=[N:6]2)[C:11](=[O:14])[N:10]=1)[CH2:23][CH3:24]

Participants

4

Reactant 3

HCID 713FormamideHCID 1118Sulfuric AcidHCID 1363645694,5-Diamino-2-(propoxyphenyl)pyrimidin-6-one sulphate

Product 1

HCID 18409955HCID 18409955, compound

Procedure

A stirred mixture of 4,5-diamino-2-(2-propoxyphenyl)-pyrimidin-6-one sulphate (1.5 g) (prepared by the addition of concentrated sulphuric acid to an ethanolic solution of the free base) and formamide (15 ml) was heated in an oil bath (temp. 190°-200° C.) for 70 minutes. When cool the mixture was filtered and the collected solid was washed with ethanol to give a crude product 91.1 g), m.p. 254-259° C., which was recrystallised from ethanol to give the title compound, 0.72 g, m.p. 263-265° C.

Workup

  1. temperaturewas heated in an oil bath (temp. 190°-200° C.) for 70 minutes
  2. temperatureWhen cool the mixture
  3. filtrationwas filtered
  4. washthe collected solid was washed with ethanol
  5. customto give a crude product 91.1 g), m.p. 254-259° C., which
  6. customwas recrystallised from ethanol

Sources & evidence

ORD record
ord-41e72c452bf04e07a4e2b82dee9008dd
Source dataset
uspto-grants-2001_03
Patent number
US06200980B1

Reaction notes

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