Oxalyl chloride → 5-Acetyl-2-ethoxybenzoyl chloride

HRID 1532135노트

반응식

HRID 1532135 반응식
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[C:7]([C:10]1[CH:11]=[CH:12][C:13]([O:19][CH2:20][CH3:21])=C([CH:18]=1)C(O)=O)(=[O:9])[CH3:8]>ClCCl.CN(C)C=O>[C:7]([C:10]1[CH:11]=[CH:12][C:13]([O:19][CH2:20][CH3:21])=[C:1]([CH:18]=1)[C:2]([Cl:4])=[O:3])(=[O:9])[CH3:8]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 185365885-Acetyl-2-ethoxybenzoic acid

생성물 1

HCID 212508125-Acetyl-2-ethoxybenzoyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 6344Dichloromethane용매

실험 절차

Oxalyl chloride (3.66 g, 0.029 mol) was added dropwise to a stirred solution of 5-acetyl-2-ethoxybenzoic acid (3.0 g, 0.014 mol) in dichloromethane (15 ml) and dimethylformamide (0.1 ml). After 3 hours at room temperature, the solvent was removed by evaporation under vacuum and the residue azeotroped with hexane (3×30 ml) to give the title compound, which was used without further purification.

후처리

  1. customthe solvent was removed by evaporation under vacuum
  2. customthe residue azeotroped with hexane (3×30 ml)

출처 및 근거

ORD 기록
ord-747f7ef813954b4ca48c25ec1227daf5
출처 데이터셋
uspto-grants-2001_03
특허 번호
US06200980B1

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