反应详情

5-(2-Ethoxy-5-nitrophenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (0.64 g, 0.0018 mol) was dissolved in ethanol (50 ml) and the solution stirred with 5% palladium on charcoal catalyst (0.050 g) under hydrogen at room temperature and 50 p.s.i. pressure for 4 hours. The mixture was filtered to remove the catalyst, the filtrate evaporated under vacuum, and the residue triturated with ether to give the title compound as an off-white solid (0.56 g, 95%), m.p. 147-148° C. Found: C,62.63; H,6.60; N,21.57. C17H21N5O2 requires C,62.36; H,6.47; N, 21.39%.

1. filtrationThe mixture was filtered
2. customto remove the catalyst
3. customthe filtrate evaporated under vacuum
4. customthe residue triturated with ether