1,3-Dibromopropane → 1-(3-bromopropoxy)-4-phenoxy-2-propylBenzene

HRID 1532144노트

반응식

HRID 1532144 반응식
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[C:10]([CH2:15][CH2:16][CH3:17])[CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:18][CH2:19][CH2:20][CH2:21]Br.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C>[C:2]1([O:1][C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:21][CH2:20][CH2:19][Br:18])=[C:10]([CH2:15][CH2:16][CH3:17])[CH:9]=2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 80011,3-DibromopropaneHCID 10796Cesium carbonateHCID 154629044-Phenoxy-2-propylphenol

생성물 1

HCID 187722731-(3-bromopropoxy)-4-phenoxy-2-propylBenzene

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 4-phenoxy-2-propylphenol (12.0 g, 52.60 mmol), 1,3-dibromopropane (31.86 g, 157.81 mmol) and cesium carbonate (18.0 g, 55.23 mmol) in dry DMF (110 mL) was stirred at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and 0.2N HCl. The organic was washed twice with water, then dried over sodium sulfate. The organic was filtered and evaporated to an oil which was chromatographed over silica gel with methylene chloride/hexane (1:1) to afford the title compound.

후처리

  1. customThe reaction mixture was partitioned between ethyl acetate and 0.2N HCl
  2. washThe organic was washed twice with water
  3. dry with materialdried over sodium sulfate
  4. filtrationThe organic was filtered
  5. customevaporated to an oil which
  6. customwas chromatographed over silica gel with methylene chloride/hexane (1:1)

출처 및 근거

ORD 기록
ord-c931f71a66aa4b679f58126139f50185
출처 데이터셋
uspto-grants-2001_03
특허 번호
US06200998B1

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