反应详情

温度

90 °C

To a solution containing 1.0 g 4-fluoro-3-chlorobenzaldehyde and 45 ml DMSO, was added 1.93 g methanesulfinic acid sodium salt with stirring at 90° C. The solution was stirred 6 hours at 90° C. and poured into water. Sodiumhydrogencarbonate was added and the product was extracted with ethyl acetate. The extract was evaporated to dryness in vacuo. The residue was triturated with 2-propanol, yield 1.06 g. 1H-NMR (DMSO-d6, 400 MHz): 3.45 (s, 3H, CH3), 8.09-8.27 (m, 3 H, Ar), 10.01 (d, 1 H, CHO).

1. stirringThe solution was stirred 6 hours at 90° C.
2. additionSodiumhydrogencarbonate was added
3. extractionthe product was extracted with ethyl acetate
4. customThe extract was evaporated to dryness in vacuo
5. customThe residue was triturated with 2-propanol, yield 1.06 g