HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-6-chlorobenzoic acid → 2-Amino-6-chloro-N-(2-[tricyclo[3.3.1.13,7]dec-1-yl]ethyl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-6-chlorobenzoic acid | HCID 75071 | — |
| Reactant | 2-(Adamantan-1-yl)ethan-1-amine hydrochloride | HCID 2771138 | — |
| Product | 2-Amino-6-chloro-N-(2-[tricyclo[3.3.1.13,7]dec-1-yl]ethyl)-benzamide | HCID 20670057 | — |
Reaction Steps
Prepared according to the method of Example 14 from 1-adamantaneethylamine hydrochloride (CN 26482-53-1) (0.105 g) and 2-amino-6-chlorobenzoic acid (0.132 g) and purified by supercritical fluid chromatography eluting with CO2 in ethanol to give the title compound, contaminated with 0.35 mol equivalents of imidazole, as a white solid (0.046 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06201024B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-487c472ee37a4709b934a5f67e88459d |
| Source note | uspto-grants-2001_03 |