Chloroacetaldehyde → HCID 54557735, compound

Participants

Reaction Steps

Prepared according to the method described in Example 63 from 3- amino-2-chloro-N-(tricyclo[3.3.1.3,7]dec-1-yl)methylbenzamide from Example 54 (0.7 g), 50% chloroacetaldehyde in water (0.353 ml), sodium cyanoborohydride (0.159 g), 50% hydrochloric acid in methanol (0.385 ml) and methanol (10 ml), giving the subtitled compound as a white solid (0.777 g) after purification by flash column chromatography eluting with 3:1 iso-hexane: ethylacetate.

Provenance & Evidence