HCID 53814372, compound → HCID 54204106, compound

Participants

Reaction Conditions

Reaction Steps

13 g of ethyl 2-[(S)-2-[2-(6-amidino-1-methylindol-2-yl)ethyl]-pyrrolidinyl]-2-phenylacetate obtained in Example 2 was dissolved in 5 ml of 35% hydrochloric acid solution, and the resulting solution was heated to 60° C. and stirred for 1.5 hours, and then stirred at room temperature overnight. The reaction solvent was removed by distillation under reduced pressure. The residue was purified with column chromatography [eluent: dichloromethane/methanol(2:3)] on NH-DM1020 silica. The fractions containing the desired product were combined and then distilled under reduced pressure to obtain 6.2 mg of the title compound as a pale yellow solid.

Provenance & Evidence