Citric Acid → HCID 54099483, compound

Participants

Reaction Steps

In a 50 ml flask, 80 mg of ethyl 3-[(S)-2-[2-(6-amidino-1-ethylindol-2 -yl)ethyl]pyrrolidinyl]-2-cyclopentyl-3-oxopropanoate obtained in Example 33 was dissolved in 20 ml of ethanol, and 10 ml of 2N NaOH was added thereto. The reaction mixture was stirred for 10 hours at room temperature, neutralized with 10% aqueous citric acid solution, and then distilled under reduced pressure to remove the solvent. The residue was then purified with column chromatography [eluent: ethyl acetate/methanol (5:1)] on NH-DM1020 silica to obtain 51 mg of the title compound as a yellowish white solid.

Provenance & Evidence