Sodium Hydroxide → HCID 54519008, compound

Participants

Reaction Steps

40 mg of ethyl 2-[[2-[(S)-2-[2-(6-amidino-1-ethylindol-2-yl)ethyl]pyrrolidinyl]-2-oxoethyl]cyclopropylamino]acetate obtained in Example 43 was dissolved in 50 ml of ethanol, and 2 ml, of 2N NaOH was added thereto. The reaction mixture was stirred for 2 hours and then evaporated under reduced pressure to remove the solvent. The residue was purified with column chromatography [eluent: ethanol] on NH—DM 1020 silica to obtain 25 mg of the title compound as a pale yellow solid.

Provenance & Evidence