2-Naphthalenesulfonyl chloride → HCID 70095056, compound

Participants

Reaction Steps

In a 25 ml flask, 30 mg of 1-methyl-2-((S)-2-pyrrolidin-2-ylethyl)indole-6-carbonitrile and 36 mg of 2-naphthalenesulfonyl chloride were dissolved in 3 ml of dichloromethane, and 0.055 ml of triethylamine was added at room temperature. The reaction mixture was stirred for 2 hours, diluted with water and then extracted three times with dichloromethane. The extracts were combined, dried over MgSO4 and then evaporated. The residue was purified with silica gel column chromatography [eluent: ethyl acetate/n-hexane (1:3)]. The fractions containing the pure desired product were combined and then evaporated to obtain 26.9 mg of the title compound as a pale yellow solid.

Provenance & Evidence