Sodium Hydroxide → HCID 54574145, compound

Participants

Reaction Steps

In a 50 ml flask; 140 mg of ethyl 2-[(R)-2-[[(S)-2-[2-(6-amidino-1-ethylindol-2-yl)ethyl]piperidyl]carbonyl]pyrrolidinyl]acetate was dissolved in 10 ml of ethanol, and 0.5 ml of 2N NaOH was added thereto. The reaction solution was stirred for 3 hours at room temperature and evaporated under reduced pressure to remove the solvent. The residue was purified with column choromatography [eluent: ethyl acetate/methanol (1:1)] on NH-DM1020 silica to obtain 60 mg of the title compound as a yellowish white solid.

Provenance & Evidence