Ethyl 2-bromopropionate → HCID 20640424, compound

Participants

Reaction Conditions

Reaction Steps

300 mg (0.823 mmole) of 1-ethyl-2-[2-[(S)-1-[((R)-pyrrolidin-2-yl)carbonyl]pyrrolidin-2-yl]ethyl]indole-6-carbonitrile was dissolved in 15 ml of acetonitrile, and 0.29 ml (1.646 mmole) of diisopropylethylamine and 0.22 ml (1.646 mmole) of ethyl 2-bromopropionate were added thereto. The reaction mixture was heated to 70° C., stirred for 4 hours, and then concentrated under reduced pressure. The residue was purified with silica gel column chromatography [eluent: dichloromethane/methanol(20:1)] to obtain 310 mg of the title compound as a pale yellow oil.

Provenance & Evidence