HCID 54450420, compound → HCID 70106345, compound

Participants

Reaction Steps

130 mg(0.269 mmole) of 2-[(R)-2-[[(S)-2-[2-(6-amidino-1-ethylindol-2-yl)ethyl]pyrrolidinyl]carbonyl]pyrrolidinyl]-4-hydroxybutanoic acid was dissolved in 5 ml of 3N—HCl, and the resulting solution was stirred for 18 hours at room temperature and then evaporated under reduced pressure to remove the solvent. The residue was purified with column chromatography [eluent: ethyl acetate/methanol(3:1) on NH-DM1020 silica to obtain 70 mg of the title compound as a white solid.

Provenance & Evidence