Water → HCID 54282592, compound

Participants

Reaction Conditions

Reaction Steps

52 mg of ethyl 2-[(R)-2-[[(S)-2-[2-(6-amidino-1-ethylindol-2-yl)ethyl]pyrrolidinyl]carbonyl]pyrrolidinyl]acetate obtained in Example 60 was dissolved in dry dichloromethane. To the resulting solution was added 31 μl of triethylamine, and the mixture was cooled to −78° C. After 16 μl of acetyl chloride was added, the reaction solution was stirred for 3 hours and warmed to room temperature. Water was added and the mixture was extracted with dichloromethane. The extract was dried over MgSO4 and evaporated under reduced pressure to remove the solvent. The residue was purified with silica gel column chromatography [eluent: ethyl acetate/methanol(50:1)] to obtain 7 mg of the title compound as a pale yellow solid.

Provenance & Evidence