Hydrochloric Acid → HCID 69951850, compound

Participants

Reaction Steps

A solution of 42.8 mg (0.0760 mmol) of 1-(7-azabicyclo[2.2.1]hept-7-yl)-2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-3-yl)butylamino]ethyl]-1H-indol-5-yl]-2-methylpropan-1-one in 1.5 mL of methanol was treated with 0.152 mL (0.304 mmol) of 2 N hydrochloric acid. The solution was agitated and allowed to stand briefly before being filtered. The filtrate was evaporated to dryness under nitrogen, and the residue was triturated with diethyl ether. The resulting solid was collected on a filter, washed with additional ether, and dried to yield 46.5 mg (96%) of light golden-tan powder, mp>160° C. (gradual; preliminary softening). 500 MHz 1H NMR (DMSO-d6) was consistent with the assigned structure.

Provenance & Evidence