6-Aminohexanoic Acid → HCID 21251990, compound

Participants

Reaction Steps

To a solution of potassium carbonate (3.62 g), potassium hydroxide (3.38 g), 2,4-dichlorobenzoic acid (VI) (5.0 g) and 6-amino-n-caproic acid (13.8 g) in water (50 ml) was added cupric chloride (0.05 g) and the resulting solution was refluxed for 18 hours. After this reaction solution was cooled to room temperature, the copper salt was removed by filtration and concentrated hydrochloric acid (25 ml) was added to the resulting filtrate. Then; the resulting precipitate was collected by filtration, washed with water and dried under vacuum to give 4.8 g of the desired compound (yield, 64%).

Provenance & Evidence