Hydrochloric Acid → HCID 10978024, compound

Participants

Reaction Steps

A solution of 2-carboxymethylamino-4-chlorobenzoic acid (VIII) (5 g), 25% aqueous sodium hydroxide (8.57 g) and sodium cyanate (1.67 g) in water (65 ml) was reacted at 35° C. for one hour, adjusting to pH 5.7 with concentrated hydrochloric acid. Then, the reaction was conducted by 5 times-addition of sodium cyanate (0.42 g) every 30 minutes. 25% aqueous sodium hydroxide (7.88 g) was added to this reaction solution, the reaction was conducted at 60 to 65° C. for one hour, and then concentrated hydrochloric acid (12.8 g) was added at 60° C., the resulting crystal was collected by filtration, washed with water and dried under vacuum to give 4.78 g of 7-chloro-1-carboxymethyl-2,4 (1H, 3H)-quinazolinedione (yield, 87.6%).

Provenance & Evidence