Hydrochloric Acid → HCID 10978024, compound

Participants

Reaction Steps

To a suspension of 2-carboxymethylamino-4-benzoic acid (VIII) (7 g) in water (60 ml) was added 25% aqueous sodium hydroxide (5.95 g) to adjust to pH 5.7. A solution of sodium cyanate (4.58 g) in water (37 ml) was added dropwise to the resulting solution at 35° C. over 2.5 hours. During this dropwise addition, the pH of the reaction solution was adjusted to 5.7 with concentrated hydrochloric acid. After the completion of dropping, the reaction was further continued at the same temperature and pH for one hour. Then, 25% aqueous sodium hydroxide (10.8 g) was added in the solution and the resulting solution was reacted at 60° C. for 10 minutes, hereinafter, was treated in the same manner as in Example 20 to give 6.0 g of the desired compound (yield, 80.3%).

Provenance & Evidence