Hydrochloric Acid → HCID 10978024, compound

Participants

Reaction Steps

To a suspension of 2-carboxymethylamino-4-chlorobenzoic acid (VIII) (3.5 g) in water (68 ml) was added 25% aqueous sodium hydroxide (2.47 g)to adjust to pH 5.0. Sodium cyanate (4.77 g) was added to the resulting solution and the resulting solution was reacted at 35° C. for one hour, adjusting the pH to 6.0 with concentrated hydrochloric acid. Then, to the reaction solution was added 25% aqueous sodium hydroxide (5.4 g) and the resulting solution was reacted at 60° C. for 10 minutes. The resulting reaction solution was treated in the same manner as in Example 21 to give 2.65 g of the desired compound (yield, 70.9%).

Provenance & Evidence