Hydrochloric Acid → HCID 10978024, compound

Participants

Reaction Steps

First, to a suspension of 2-carboxymethylamino-4-chlorobenzoic acid (VIII) (0.5 g) in water (10 ml) was added 25% aqueous sodium hydroxide (0.85 g) to adjust to pH 6.8 with concentrated hydrochloric acid. Then, urea (2.54 g) was added, the resulting solution was reacted at reflux temperature for 21 hours (pH 10 at that time), concentrated hydrochloric acid was added to give a crystal. The resulting crystal was collected by filtration, washed with water and dried to give 324 mg of 1-carboxymethyl-7-chloro-2,4(1H, 3H)-quinazolinedione (yield, 60%).

Provenance & Evidence