Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,3-Dihydroisobenzofuran | HCID 10327 | — |
| Reactant | N-Hydroxyphthalimide | HCID 10665 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Phthalaldehyde | HCID 4807 | 80% |
| Product | Phthalide | HCID 6885 | 7% |
Reaction Steps
A mixture of 10 mmol of phthalan (isocoumaran), 1 mmol of N-hydroxyphthalimide (NHPI), and 5 ml of acetonitrile was stirred at 60° C. under a nitrogen monoxide atmosphere (1 atm) for 6 hours. Gas chromatographic analysis of products in the reaction mixture revealed that phthalan was converted, at a rate of 90%, into phthalaldehyde (yield: 80%), and phthalide (1-phthalanone) (yield: 7%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06201156B1 |
|---|
| Source dataset | uspto-grants-2001_03 |
|---|
| ORD ID | ord-04915df794fa4210b0f43794149e6178 |
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| Source note | uspto-grants-2001_03 |
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