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Trimethylsilylacetylene → 4-Ethynyl-4'-propylbicyclohexyl-4-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trimethylsilylacetylene | HCID 66111 | — |
| 反応物 | [1,1'-Bicyclohexyl]-4-one,4'-propyl-, | HCID 4354185 | — |
| 反応物 | Tetrabutylammonium Fluoride Trihydrate | HCID 11726816 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-Ethynyl-4'-propylbicyclohexyl-4-ol | HCID 18364504 | — |
反応手順
24.32 ml of (trimethylsilyl)acetylene are added dropwise at −30° C. to a solution of 30.0 g of 4′-propylbicyclohexyl-4-one and 3.41 g of tetrabutylammonium fluoride trihydrate in 300 ml of THF. The cooling bath is removed after 5 minutes, and the reaction mixture is stirred at RT for 2 hours. A suspension of 39.2 g of potassium fluoride in methanol is subsequently added, and the mixture is stirred at RT for 3 days. Conventional work-up gives 4-ethynyl-4′-propylbicyclohexyl-4-ol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06203724B1 |
| 出典データセット | uspto-grants-2001_03 |
| ORD ID | ord-7318a6bb722d4e8aa364de8945e408bd |
| 出典メモ | uspto-grants-2001_03 |