Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → 4-Ethynyl-4-methoxy-4'-propylbicyclohexyl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | 4-Ethynyl-4'-propylbicyclohexyl-4-ol | HCID 18364504 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 4-Ethynyl-4-methoxy-4'-propylbicyclohexyl | HCID 18364508 | — |
반응 단계
28.85 ml of a 15% solution of butyllithium in hexane are added dropwise to a solution, cooled to −30° C., of 13.0 g of 4-ethynyl-4′-propylbicyclohexyl-4-ol in 24 ml of THF. A solution of 4.67 ml of iodomethane in 36 ml of dimethyl sulfoxide is subsequently added dropwise to the reaction mixture at −5° C. The mixture is stirred at RT overnight and subjected to conventional work-up, giving 4-ethynyl-4-methoxy-4′-propylbicyclohexyl.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06203724B1 |
| 출처 데이터셋 | uspto-grants-2001_03 |
| ORD ID | ord-68d9a2b1f9ab4166b4bd88f4ea21e0bd |
| 출처 메모 | uspto-grants-2001_03 |