HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 4-[4-(4,4'-Dipentylbicyclohexyl-4-ylethynyl)-3-fluorophenylethynyl]-4-methoxy-4'-propyl-bicyclohexyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 4-Ethynyl-4-methoxy-4'-propylbicyclohexyl | HCID 18364508 | — |
| Reactant | 4-(4-Bromo-2-fluorophenylethynyl)-4,4'-dipentylbicyclohexyl | HCID 22013388 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 4-[4-(4,4'-Dipentylbicyclohexyl-4-ylethynyl)-3-fluorophenylethynyl]-4-methoxy-4'-propyl-bicyclohexyl | HCID 22013390 | — |
Reaction Steps
Analogously to Example 4, 1.913 g of 4-(4-bromo-2-fluorophenylethynyl)-4,4′-dipentylbicyclohexyl are reacted with 0.997 g of 4-ethynyl-4-methoxy-4′-propylbicyclohexyl in the presence of 0.219 g of tetrakis(triphenylphosphine)palladium(0) and 5 ml of pyrrolidine, giving 4-[4-(4,4′-dipentylbicyclohexyl-4-ylethynyl)-3-fluorophenylethynyl]-4-methoxy-4′-propyl-bicyclohexyl (C 177 N (36) I, Δε −0.26, Δn −0.015).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06203724B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-0950396a12044c6da6857bf0ebd79153 |
| Source note | uspto-grants-2001_03 |