(1s,4r)-4-Propylcyclohexane-1-carboxylic acid → HCID 22013395, compound

Participants

Reaction Steps

1.10 g of 1-(4,4′-dipentylbicyclohexyl-4-ylethynyl)-4-pentylcyclohexanol and 0.394 g of 4-propylcyclohexanecarboxylic acid are dissolved in 4 ml of dichloromethane, and 0.283 g of 4-(dimethylamino)pyridine is added. 5.569 g of N,N-dicyclohexylcarbodiimide dissolved in 3 ml of dichloromethane are then added dropwise to the reaction mixture. The mixture is stirred overnight and subjected to conventional work-up, giving 1-(4,4′-dipentylbicyclohexyl-4-ylethynyl)-4-pentylcyclohexyl 4-propylcyclohexanecarboxylate (C 66 SmB 171 I, Δε −0.02).

Provenance & Evidence