Hydrochloric Acid → HCID 21712165, compound

Participants

Reaction Conditions

Reaction Steps

6.75 g of 3-(3-fluoro-5-chloro-2-pyridyl)-4-methyl-5methoxycarbonyl-1-methyl-[1H]-pyrazole are suspended in 40 ml of dimethyl sulfoxide. 14.3 ml of a 2 molar sodium hydroxide solution are added dropwise, while cooling occasionally in an ice-bath (temperature <30° C.). The thick yellow-brown suspension is stirred at 22° C. for 2 hours. The resulting suspension is then introduced into ice-water and the pH is brought to 1 with 2 molar hydrochloric acid. The slurry formed is filtered with suction and the solid is washed thoroughly with cold water and then dried in vacuo at 60° C. 5.97 g of the desired title compound are obtained as a beige solid of melting point 194-196° C.

Provenance & Evidence