Alpha-Cyclodextrin → (+)-Lactose

HRID 1532584Notes

Reaction equation

HRID 1532584 reaction equation
C([O-])(=O)C(CCC)CCC.[Na+].[CH2:12]([OH:77])[C@H:13]1[O:18][C@@H:17]2[O:19][C@H:20]3[C@H:25]([OH:26])[C@@H:24]([OH:27])[C@@H:23]([O:28][C@H:29]4[C@H:34]([OH:35])[C@@H:33]([OH:36])[C@@H:32]([O:37][C@H:38]5[C@H:43]([OH:44])[C@@H:42]([OH:45])[C@@H:41]([O:46][C@H:47]6[C@H:52]([OH:53])[C@@H:51]([OH:54])[C@@H:50]([O:55][C@H:56]7[C@H:62]([OH:63])[C@@H:61]([OH:64])[C@@H:59]([O:60][C@H:14]1[C@H:15]([OH:76])[C@H:16]2[OH:75])[O:58][C@@H:57]7[CH2:65][OH:66])[O:49][C@@H:48]6[CH2:67][OH:68])[O:40][C@@H:39]5[CH2:69][OH:70])[O:31][C@@H:30]4[CH2:71][OH:72])[O:22][C@@H:21]3[CH2:73][OH:74]>O>[OH:19][CH:17]1[O:18][C@H:13]([CH2:12][OH:77])[C@@H:14]([O:60][C@@H:59]2[O:58][C@H:57]([CH2:65][OH:66])[C@H:56]([OH:55])[C@H:62]([OH:63])[C@H:61]2[OH:64])[C@H:15]([OH:76])[C@H:16]1[OH:75].[CH2:67]([OH:68])[C@H:48]1[O:49][C@@H:50]2[O:55][C@H:56]3[C@H:62]([OH:63])[C@@H:61]([OH:64])[C@@H:59]([O:60][C@H:14]4[C@H:15]([OH:76])[C@@H:16]([OH:75])[C@@H:17]([O:19][C@H:20]5[C@H:25]([OH:26])[C@@H:24]([OH:27])[C@@H:23]([O:28][C@H:29]6[C@H:34]([OH:35])[C@@H:33]([OH:36])[C@@H:32]([O:37][C@H:38]7[C@H:43]([OH:44])[C@@H:42]([OH:45])[C@@H:41]([O:46][C@H:47]1[C@H:52]([OH:53])[C@H:51]2[OH:54])[O:40][C@@H:39]7[CH2:69][OH:70])[O:31][C@@H:30]6[CH2:71][OH:72])[O:22][C@@H:21]5[CH2:73][OH:74])[O:18][C@@H:13]4[CH2:12][OH:77])[O:58][C@@H:57]3[CH2:65][OH:66]

Participants

5

Reactant 2

HCID 444913Alpha-CyclodextrinHCID 16760703Sodium valproate

Product 2

HCID 440995(+)-LactoseHCID 444913Alpha-Cyclodextrin

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

166 g (1 mole) sodium valproate and 90 g (moisture content<5%, 0.09 mole) a α-cyclodextrin are blended and 20 mL water is added. The ingredients are thoroughly kneaded, and the product is obtained by drying and grinding as described in Example 1. The moisture absorption after 24 hour storage at 40° C. under 75% relative humidity was found to be 43%, compared to 70% and 47% of sodium valproate itself and of the product obtained in a similar way with lactose instead of a α-cyclodextrin, respectively. The latter two were liquified.

Workup

  1. customthe product is obtained
  2. customby drying
  3. customgrinding
  4. customThe moisture absorption after 24 hour storage at 40° C. under 75% relative humidity

Sources & evidence

ORD record
ord-6f30f466fc1f4d8ea80dd3343d197fba
Source dataset
uspto-grants-2001_03
Patent number
US06204255B1

Reaction notes

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