Methanol → HCID 70022026, compound

Participants

Reaction Steps

2-(Isopropylamino)-4,5,6-trichloro-1-(2,3,5-tri-O-acetyl-beta-L-ribofuranosyl)-1H-benzimidazole (1.00 g, 1.86 mmol), sodium carbonate (0.26 g, 2.45 mmol), water (4 mL), methanol (6 mL) and ethanol (8mL) were used according to general procedure III. The product was purified by silica gel chromatography using 10:1 dichloromethane/methanol to afford 0.57 g (75%) of a white powder; m.p. 223-224° C. Anal. Calcd for C15H18Cl3N3O4: C, 43.87; H, 4.42; N, 10.23. Found: C, 43.63; H, 4.55; N, 9.98.

Provenance & Evidence