HCID 22013773, compound → HCID 22013746, compound

HRID 1532695Notes

Reaction equation

HRID 1532695 reaction equation
[CH3:1][N:2]([CH3:20])[CH2:3][CH2:4][NH:5][C:6]1[CH:16]=[CH:15][C:9]([C:10]([N:12]([CH3:14])[CH3:13])=[O:11])=[CH:8][C:7]=1[N+:17]([O-])=O>C(O)C.[C].[Pd]>[NH2:17][C:7]1[CH:8]=[C:9]([CH:15]=[CH:16][C:6]=1[NH:5][CH2:4][CH2:3][N:2]([CH3:20])[CH3:1])[C:10]([N:12]([CH3:14])[CH3:13])=[O:11]

Participants

4

Reactant 1

HCID 22013773HCID 22013773, compound

Product 1

HCID 22013746HCID 22013746, compoundYield 103.3%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

10% of palladium-carbon (0.535 g) was added to a solution containing 4-{[2-(dimethylamino)ethyl]amino}-N,N-dimethyl-3-nitrobenzamide (2.672 g) in ethanol (27 ml) and the mixture was stirred for 5.5 hours under a hydrogen gas atmosphere at room temperature. After the catalyst was removed out by filtration, the filtrate was concentrated, thereby yielding the entitled compound (2.464 g) as blackish brown oil.

Workup

  1. customAfter the catalyst was removed out by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-89184bdc515949dbb33433a613935788
Source dataset
uspto-grants-2001_03
Patent number
US06204264B1

Reaction notes

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