Potassium Carbonate → HCID 22666129, compound

Participants

Reaction Steps

DPPA (123 mg, 0.45 mmols) was added to a DMF (1 ml) solution of 8-bromooctanoic acid (100 mg, 0.45 mmols) and potassium carbonate (68 mg, 0.49 mmols), and stirred at room temperatures for 3 hours. The reaction mixture was diluted with water, and extracted with ether. The organic layer was washed with water, and dried with anhydrous magnesium sulfate, and the solvent was evaporated. A chloroform (2 ml) solution of the resulting 8-bromooctanoic acid azide (95 mg, 0.38 mmols) was heated under reflux for 30 minutes, to which was added a chloroform (1 ml) solution of 2,6-diisopropylaniline (68 mg, 0.38 mmols), and heated under reflux for further 15 hours. After the reaction, the solvent was evaporated, and the residue was purified through preparative thin-layer chromatography (developer: chloroform/methanol=20/1) to obtain 112 mg (yield: 63%) of N-(7-bromoheptyl)-N′-(2,6-diisopropylphenyl)urea as colorless powdery crystals.

Provenance & Evidence