Sodium Hydroxide → HCID 10763236, compound

Participants

Reaction Steps

Dimethyl 2-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyl]malonate (6.00 g, 14.2 mmol) synthesized according to the method described in WO95/18125 was dissolved in methanol (60 ml) and tetrahydrofuran (30 ml). 2N Aqueous sodium hydroxide solution (17.7 ml, 35.5 mmol) was added at room temperature. The mixture was stirred for 68 hr and the solvent was evaporated. Water (100 ml) was added to the residue and acidified with 1N hydrochloric acid. The precipitated white solid was collected by filtration, washed with water and recrystallized from ethyl acetate-hexane to give the title compound (3.00 g, yield 53%) as a white powder.

Provenance & Evidence