HCID 10794469, compound → HCID 22013853, compound

Participants

Reaction Steps

Dibenzyl 2-ethoxycarbonylmethyl-2-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyl]malonate (29.5 g, 44.6 mmol) obtained in Example 9 was dissolved in methanol (150 ml) and tetrahydrofuran (150 ml), and 5% palladium carbon (2.0 g) was added. The mixture was vigorously stirred at room temperature under a hydrogen atmosphere (3.3-3.4 atm) for 6 hr. After stirring, the catalyst was removed with celite and the solvent was evaporated to give the title compound (21.0 g, yield 98%) as an orange-yellow solid.

Provenance & Evidence