Urea → HCID 22013874, compound

Participants

Reaction Conditions

Reaction Steps

To 3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propionic acid (1.00 g, 2.85 mmol) obtained in Example 17 was added thionyl chloride (1.7 ml), and the mixture was stirred under heating for 1 hr at 100° C. Excess thionyl chloride was evaporated under reduced pressure and urea (257 mg, 4.28 mmol) was added to the obtained residue. The mixture was stirred under heating for 1 hr at 120° C. and purified by silica gel column chromatography (developing solvent; dichloromethane: methanol=10:1) to give the title compound (560 mg, yield 50%) as a white solid.

Provenance & Evidence