HCID 70224837, compound → tert-Butyl methyl 2-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyl]malonate

Participants

Reaction Steps

To a suspension of 10% palladium carbon (1.1 g) in tetrahydrofuran (4.0 ml) was added a mixed solution of tert-butyl methyl 2-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene]malonate in methanoltetrahydrofuran (2:1, 36.0 ml), and the mixture was stirred at room temperature for 14 hr under hydrogen pressurization (3 atm). After completion of the reaction, the palladium carbon catalyst was filtered through celite and the filtrate was concentrated under reduced pressure to give the title compound (5.4 g, quant) as a yellow oil.

Provenance & Evidence