Diethyl Malonate → HCID 10551486, compound

Participants

Reaction Steps

4-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]benzaldehyde (8.0 g, 26.0 mmol) synthesized according to the method described in WO95/18125, diethyl malonate (4.79 g, 29.9 mmol), acetic acid (1.04 ml) and piperidine (1.03 ml) were mixed. While removing water through Dean-Stark trap, the mixture was refluxed under heating. Three and a half hours later, toluene was evaporated and the obtained residue was recrystallized from ethyl acetate-hexane to give the title compound (9.55 g, yield 82%) as pale-brown white crystals.

Provenance & Evidence